NeuroMab™ Anti-IL-6 BBB Shuttle Antibody(NRZP-1022-ZP2895)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Immunogen

IL-6/IL-6Ralpha Complex

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse; Humanized; Chimeric

Applications

Antagonist; In Vivo; In Vitro; Block; Inhib

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

IL-6

Official Name

IL6

Full Name

Interleukin 6 (IL-6)

Alternative Names

IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6

Product Pictures

Inhib

Figure 8 shows the results of experiments reflecting the in vivo inhibition of haptoglobin secretion by exemplary antibodies.

ELISA

Figure 1 shows the results of experiments reflecting the binding of exemplary antibodies to Fc-IL6Ralpha-IL6.

ELISA

Figure 2 shows the results of experiments reflecting the binding of exemplary antibodies to IL-6.

ELISA

Figure 3 shows the results of experiments reflecting the binding of exemplary antibodies of the invention to non-covalently complexed IL-6 and IL-6Rα.

Block

Figure 4 shows the results of experiments illustrating the ability of exemplary antibodies to block haptoglobin release from HepG2 cells stimulated with Fc-IL6Ralpha-IL6 complexes.