NeuroMab™ Anti-IL-6R BBB Shuttle Antibody(NRZP-1022-ZP2913)
[CAT#: NRZP-1022-ZP2913]
- Host Species:
- Rabbit; Humanized
- Species Reactivity:
- Human
- Applications:
- FC; Inhib; Block; In Vitro; In Vivo; Neut
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Rabbit; Humanized
Applications
FC; Inhib; Block; In Vitro; In Vivo; Neut
Relevant Diseases
Neuroinflammation
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
CD126
Official Name
IL6R
Full Name
Interleukin 6 (IL-6)
Alternative Names
IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6
Product Pictures
ELISA
Figure 1 Humanized lead anti-IL-6R antibody candidates retain most of the activity of their rabbit counterparts.
Direct ELISA of anti-IL-6R antibodies.
FCM
Figure 2 Humanized lead anti-IL-7R antibody candidates retain most of their rabbit antibody activity.
Anti-IL-6R antibody binding to IL-6R on human myeloma U266B1 cells measured by FACS
Block
Figure 3 Humanized lead anti-IL-8R antibody candidates retain most of the activity of their rabbit counterparts.
Ability of anti-IL-6R antibodies to block IL-6 binding to IL-6R.
FuncS
Figure 4 Humanized lead anti-IL-9R antibody candidates retain most of the activity of their rabbit counterparts.
Humanized anti-IL-6R antibodies inhibit IL-6 mediated proliferation of TF-1 cells.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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