NeuroMab™ Anti-AMIGO-1 BBB Shuttle Antibody, Clone L86/33

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-AMIGO-1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 395-493 (cytoplasmic C-terminus) of mouse AMIGO-1 (also known as Amphoterin-induced protein 1, Alivin-2, Ali2, AMIGO and KIAA1163, accession number Q80ZD8)
Human: 100% identity (99/99 amino acids identical)
Rat: 100% identity (99/99 amino acids identical)
<40% identity with AMIGO-2 and AMIGO-3

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

L86/33

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

AMIGO-1

Official Name

AMIGO1

Full Name

AMIGO-1

Alternative Names

Adhesion Molecule With Ig Like Domain 1; Alivin-2; AMIGO-1; AMIGO; ALI2; Amphoterin-Induced Gene And Open Reading Frame; Amphoterin-Induced Gene And ORF; Amphoterin-Induced Protein 1; KIAA1163;

Uniprot ID

Q80ZD8

Product Pictures

Fig. 1 Tissue and transfected cell immunoblot: extracts of rat brain membrane (RBM) and COS cells transiently transfected with V5-tagged AMIGO-1, AMIGO-2, AMIGO-3 or untagged Kv2.1 plasmid and probed with L86/33 TC supe (left) and Mouse anti-V5 (right).