NeuroMab™ Anti-GFAP BBB Shuttle Antibody(NRZP-1022-ZP3933)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

WB; IHC

Relevant Diseases

Alzheimer's Disease; Neuroinflammation; Meningoencephalomyelitis

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

GFAP

Official Name

GFAP

Full Name

Glial Fibrillary Acidic Protein

Alternative Names

Glial Fibrillary Acidic Protein; Intermediate Filament Protein; ALXDRD;

Product Pictures

SDS-PAGE

Figure 1: Polyacrylamide gel electrophoresis for identification of GFAP protein expression.

SDS-PAGE

Figure 2: Polyacrylamide gel electrophoresis of GFAP-purified monoclonal antibodies.

Figure 3: Western blot of human GFAP protein detected by GFAP monoclonal antibody.

IHC

Figure 4: Comparison of immunohistochemical staining patterns of astrocytoma; the left side is anti-GFAP protein monoclonal antibody (10G1G11H7), and the right side is GFAP (6F 2).

IHC

Figure 5: Comparison of immunohistochemical staining of glioma; the left side is anti-GFAP protein monoclonal antibody (10G1G11H7), and the right side is GFAP (6F 2).

IHC

Figure 6: Comparison of pituitary immunohistochemical staining; the left side is anti-GFAP protein monoclonal antibody (10G1G11H7), and the right side is GFAP (6F 2).

IHC

Figure 7: Comparison of immunohistochemical staining of brain tissue; the left side is the anti-GFAP protein monoclonal antibody (10G1G11H7), and the right side is GFAP (6F 2 ).

Publications