NeuroMab™ Anti-GHRL BBB Shuttle Antibody(NRZP-1022-ZP3946)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA

Relevant Diseases

Eating Disorder

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

GHRL

Official Name

GHRL

Full Name

Ghrelin

Alternative Names

GHRL; MTLRP; ghrelin and obestatin prepropeptide; Ghrelin

Product Pictures

ELISA

Figure 1 shows the results of a competition ELISA using acyl ghrelin, desacylated ghrelin, and acyl ghrelin amino acids 2-28 and 3-28 to determine the binding of Fab 5611 to desacylated ghrelin

ELISA

Figure 2 shows the results of a competition ELISA using desacylated ghrelin, 1-8 (cys) desacylated ghrelin, 4-28 (cys) and 9-28 to determine the binding of Fab 5611 to desacylated ghrelin release peptide binding.