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Creative Biolabs
Product

NeuroMab™ Anti-Notch1 Antibody, Clone N585 (CBP14861)

[CAT#: NRZP-0922-ZP3550]

Host Species:
Rabbit
Species Reactivity:
Human
Applications:
WB

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Product Overview

Description

The NeuroMab™ anti-Notch1 antibody detects intracellular epitopes between 2400 and 2500 amino acids of human Notch1. It recognizes both the full-length (~300 KDa) and the NTM region (~120 KDa), which consists of a short extracellular juxtamembrane peptide, a transmembrane sequence and the intracellular domain (NICD). The antibody cannot detect the extracellular (ligand-binding) domain of Notch1 following cleavage at the S2 site by ADAM-type metalloproteases.

Expression Host

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro2439 of human Notch1.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Rabbit

Isotype

Rabbit IgG

Clone Number

CBP14861

Applications

WB
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

NOTCH1

Official Name

NOTCH1

Full Name

Notch1

Alternative Names

AOVD1; Translocation-associated notch protein TAN-1; NEXT; hN1; AOS5; NICD; Notch 1; Neurogenic locus notch homolog protein 1; TAN1

Gene ID

4851(Human)

Uniprot ID

P46531(Human)
Publications

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For Research Use Only. Not For Clinical Use.
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