NeuroMab™ Anti-SOD1 Antibody(NRP-0422-P651)

Figure 1 shows the binding results of SOD1-specific antibodies to various SOD1 proteins determined by ELISA.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.

Figure 2 Immunoprecipitation of various hSOD1 proteins expressed in human cells by immunoblotting.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.

Figure 3 shows the images of immunohistochemical staining of spinal cord tissues of various hSOD1 protein transgenic mice with ten SOD1-specific antibodies.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.

Figure 4 shows the mean body weight changes of B6SJL-Tg(SOD1G93A)1Gur/J mice treated with monoclonal antibodies.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.