NeuroMab™ Anti-TREM2 BBB Shuttle Antibody(NRZP-1022-ZP2708)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

FC; IHC; Cyt; ADCP; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

TREM2

Official Name

TREM2

Full Name

Triggering receptor expressed on myeloid cells 2

Alternative Names

TREM2; Triggering receptor expressed on myeloid cells 2

Product Pictures

Cyt

Figure 1 shows that anti-Trem2 mAb clone 7 induces ADCP of target cells by bone marrow-derived macrophages.

ELISA

Figure 2 shows the binding characteristics of anti-TREM2 antibodies (Pil.2 Clone 2, Pil.2, Clone 5, and Pil.2 Clone 7). Absolute absorbance is plotted on the Y-axis, phage clones not displaying Fab are shown as controls for non-specific binding (K07.)

Publications