NeuroMab™ Anti-TREM2 BBB Shuttle Antibody(NRZP-1022-ZP2709)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

FC; IHC; Cyt; ADCP; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

TREM2

Official Name

TREM2

Full Name

Triggering receptor expressed on myeloid cells 2

Alternative Names

TREM2; Triggering receptor expressed on myeloid cells 2

Product Pictures

FuncS

Figure 1 demonstrates that anti-NSM antibodies reduced tumor growth relative to controls to the same extent as anti-PD-1 therapy.

MC38 colon carcinomas were injected into B6 6 week old male mice. Mice, randomized into treatment groups, were treated with the indicated antibodies on day 5, 7, 11, 15 by IP injection. Shown is the 75% rank (dropping the top outlier and plotting the bottom 3 out of 4 mice). Dosing: 200ug/day for PD-1 and the Fc control, 40ug, 20ug, 20ug and 40ug injections were made for antiPi l .2 (aTREM2) antibody on days 5,7, 11, and 15. Tumors were measured by caliper and tumor volume is shown.

ELISA

Figure 2 shows the binding characteristics of anti-TREM2 antibodies (Pil.2 Clone 2, Pil.2, Clone 5, and Pil.2 Clone 7). absolute absorption

FCM

Figure 3 shows staining of transfectants with anti-TREM2 antibody (Pil.2 clone 2). EL4-TREM2+ cells are marked with an unshaded black histogram, while parental EL4 cells are marked with a shaded gray histogram.

Publications