AAV-CaMKIIα-PSAM4-GlyR-IRES-mCherry
[CAT#: NRYF-0624-HZ24]
Neuron silencing
- Tracer Type:
- Chemogenetics
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Description
The inhibitory PSAM4-GlyR is a chimeric protein of a modified α7 nicotinic acetylcholine receptor ligand binding domain fused to the chloride-permeable glycine receptor ion pore domain (GlyR). After intracranial injection and expression of a virus encoding PSAM4-GlyR, application of ultrapotent agonist (e.g., uPSEM792) activates PSAM4-GlyR, which in principle selectively inhibits PSAM4-GlyR-expressing neurons.
Tracer Type
Chemogenetics
Functional Gene
PSAM4-GlyR
Virus Type
Adeno-Associated Virus (AAV)
Promoter
CaMKIIα
Expression
Normal Expression
Properites
Color
Red
Fluorophore
mCherry
Shipping
Dry ice
Storage
-80°C
Research Use Only
For research use only
References
References
Magnus, Christopher J et al. "Ultrapotent chemogenetics for research and potential clinical applications." Science (New York, N.Y.) vol. 364,6436 (2019): eaav5282. doi:10.1126/science.aav5282IF: 44.7 Q1
Publications
Publications (0)
Neural Tracers
For Research Use Only. Not For Clinical Use.
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