iNeuMab™ Anti-KCNT2/Slo2.1/Slick sodium- and chloride-activated ATPsensitive potassium channel BBB Shuttle Antibody (NRZP-0423-ZP189)
[CAT#: NRZP-0423-ZP189]
- Species Reactivity:
- Mouse; Rat
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNT2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 564-624 (cytoplasmic C-terminus) of mouse Slo2.1 (also known as Potassium channel subfamily T member 2, Sequence like an intermediate conductance potassium channel subunit, Kcnt2 and Slick, accession number D3Z649)
Rat: 98% identity (60/61 amino acids identical)
Human: 90% identity (55/61 amino acids identical)
~50% identity with KCNT1/Slo2.2/Slack
Rat: 98% identity (60/61 amino acids identical)
Human: 90% identity (55/61 amino acids identical)
~50% identity with KCNT1/Slo2.2/Slack
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Mouse; Rat
Clonality
Monoclonal
Isotype
IgG1
Research Areas
K+ channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
KCNT2
Official Name
KCNT2
Full Name
KCNT2/Slo2.1/Slick K+ channel
Alternative Names
KCNT2; KCa4.2; SLICK; SLO2.1; potassium sodium-activated channel subfamily T member 2; EIEE57; DEE57
Uniprot ID
D3Z649
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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