Creative Biolabs

Mouse Anti-HSP90 Monoclonal Antibody (3F11C1), Unconjugated

[CAT#: NAB20101739CR]

Mouse Monoclonal (3F11C1) to HSP90

Host Species:
Mouse
Species Reactivity:
Human; Mouse; Rat; Porcine
Applications:
FC; IF; IHC; WB; ELISA

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Description
HSP90 is a constitutively and ubiquitously expressed molecular chaperone that is crucial for the stability and function of many proteins. HSP90 provides chaperoning activity for client proteins; many of them are members of oncogenic pathways, indicating its implication in tumor malignancy. HSP90 mainly resides in the cytosol, while it can also be released to the extracellular space. Secreted Hsp90 is a C-terminal truncated form. It has been reported that the level of plasma Hsp90 is positively correlated with tumor malignancy in clinical cancer patients, and can be a promising diagnostic marker for tumor malignancy in clinical application.
Expression Host
Mammalian cells
Immunogen
HSP90 fusion protein Ag3826
Species Reactivity
Human; Mouse; Rat; Porcine
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2a
Clone Number
3F11C1
Applications
FC; IF; IHC; WB; ELISA
Application Notes
IF : 1:20-1:200; IHC : 1:20-1:200; WB : 1:500-1:1000
Relevant Diseases
Neurological Disorders
Research Areas
Neural Signal Transduction
Conjugation
Unconjugated
Form
Liquid
Formulation
PBS, 0.1% sodium azide and 50% glycerol pH 7.3.
Preservatives
Yes
Concentration
1000 μg/ml
Purification
Antigen affinity purification
Purity
>95%, as determined by SDS-PAGE
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store at -20°C. Stable for one year after shipment.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
HSP90 alpha
Official Name
HSP90
Full Name
Heat shock protein 90kDa alpha (cytosolic), class A member 1
Alternative Names
Heat shock 86 kDa; HSP 86; HSP86; Hsp89; HSP89A; HSP90; HSP90A; HSP90AA1; HSP90N; HSPC1
Gene ID
3326(Human); 15516(Mouse); 301252(Rat)
Uniprot ID
P08238(Human); P11499(Mouse); P34058(Rat)
1. Feng, J., Wu, L., Ji, J., Chen, K., Yu, Q., Zhang, J.,... & Xu, L. (2019). PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research, 38(1), 1-15. 2. Cheng, L., Yuan, B., Ying, S., Niu, C., Mai, H., Guan, X.,... & Jin, R. (2019). PES1 is a critical component of telomerase assembly and regulates cellular senescence. Science advances, 5(5), eaav1090. 3. Ulanova, A., Gritsyna, Y., Vikhlyantsev, I., Salmov, N., Bobylev, A., Abdusalamova, Z.,... & Podlubnaya, Z. (2015). Isoform composition and gene expression of thick and thin filament proteins in striated muscles of mice after 30-day space flight. BioMed research international, 2015.
For Research Use Only. Not For Clinical Use.
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