Mouse Anti-HSP90 Monoclonal Antibody (CBP2665)

Product Overview

Description

HSP90 is a constitutively and ubiquitously expressed molecular chaperone that is crucial for the stability and function of many proteins. HSP90 provides chaperoning activity for client proteins; many of them are members of oncogenic pathways, indicating its implication in tumor malignancy. HSP90 mainly resides in the cytosol, while it can also be released to the extracellular space. Secreted Hsp90 is a C-terminal truncated form. It has been reported that the level of plasma Hsp90 is positively correlated with tumor malignancy in clinical cancer patients, and can be a promising diagnostic marker for tumor malignancy in clinical application.

Expression Host

Mammalian cells

Immunogen

HSP90 fusion protein Ag3826

Species Reactivity

Human; Mouse; Rat; Porcine

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP2665

Applications

FC; IF; IHC; WB; ELISA

Application Notes

IF : 1:20-1:200; IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

HSP90 alpha

Official Name

HSP90

Full Name

Heat shock protein 90kDa alpha (cytosolic), class A member 1

Alternative Names

Heat shock 86 kDa; HSP 86; HSP86; Hsp89; HSP89A; HSP90; HSP90A; HSP90AA1; HSP90N; HSPC1

Gene ID

3326(Human); 15516(Mouse); 301252(Rat)

Uniprot ID

P08238(Human); P11499(Mouse); P34058(Rat)

References

1. Feng, J., Wu, L., Ji, J., Chen, K., Yu, Q., Zhang, J.,... & Xu, L. (2019). PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research, 38(1), 1-15. 2. Cheng, L., Yuan, B., Ying, S., Niu, C., Mai, H., Guan, X.,... & Jin, R. (2019). PES1 is a critical component of telomerase assembly and regulates cellular senescence. Science advances, 5(5), eaav1090. 3. Ulanova, A., Gritsyna, Y., Vikhlyantsev, I., Salmov, N., Bobylev, A., Abdusalamova, Z.,... & Podlubnaya, Z. (2015). Isoform composition and gene expression of thick and thin filament proteins in striated muscles of mice after 30-day space flight. BioMed research international, 2015.

Publications