NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody, Clone NR47P
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse
- Applications:
- ELISA; WB; IP; In Vitro
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Fig.1 shows the results of passive immunotherapy with the antibody on memory performance in probe portion of the Morris water maze test.
Pepscan analysis showed binding of NI-202.21D11 to overlapping peptides B08 (aa 109-123 of SEQ ID NO:1), B09 (aa 113-127 of SEQ ID NO:1) and B10 (aa 117-131 of SEQ ID NO:1) of human α-synuclein suggesting that the minimal sequence required for NI-202.21D11 binding is PVDPDNE (aa 117-123 of SEQ ID NO:1) within human α-synuclein.
Fig.2 shows the results of an ELISA assay testing the affinity of different humanized 5C1 antibodies.
Pepscan analysis showed binding of NI-202.21D11 to overlapping peptides B08 (aa 109-123 of SEQ ID NO:1), B09 (aa 113-127 of SEQ ID NO:1) and B10 (aa 117-131 of SEQ ID NO:1) of human α-synuclein suggesting that the minimal sequence required for NI-202.21D11 binding is PVDPDNE (aa 117-123 of SEQ ID NO:1) within human α-synuclein.
Fig.3 shows the results of an alanine scanning mutagenesis experiment used to determine the epitope of α-synuclein bound by the 5D12 antibody.
The upper portion of the figure shows Western blots of full length α-synuclein (wild-type or individual point mutations in residues 118-126, as indicated) stained with 5D12 antibody.
