NeuroMab™ Anti-Apo E BBB Shuttle Antibody, Clone 15G8

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1k

Clone Number

15G8

Applications

WB; IP

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

Apo E

Official Name

APOE

Full Name

Apolipoprotein E

Alternative Names

APOE; AD2; APO-E; LDLCQ5; LPG; apolipoprotein E; ApoE4

Product Pictures

Figure 1 shows the immunoprecipitation blots of full-length ApoE3, full-length ApoE4, ApoE3(1-272) and ApoE4(1-272).

Figure 2 shows the results from wild-type mice ("wt"), apoE knockout mice ("KO"), and transgenic mice expressing human ApoE knock-in (E2, E3, and E4 strains) and human amyloid-β. Western blot of tissue lysates using mAbs 12C12 (left panel), 15E10 (middle panel) and 15G8 (right panel).

Publications