iNeu™ Microglia AD APOE E4/E4 Kit, Donor 1, Disease Model

[CAT#: NCL-7P031]

Female, APOE 4/4, Alzheimer's Disease (AD)

Species:: Human

Cell Types:: Microglia

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Inquiry

Product Overview

Description

APOE RS429358: C/C
APOE RS7412: C/C
APOE Genotype: 4/4
TREM2 (P.R47H) RS7593268: C/C
CD33 RS12459419: C/C

Neurological Disease Models

AD-related Cells

Cell Types

Microglia

Application Notes

Normal CNS Functions
Synaptic remodeling and pruning
Neurotransmitter homeostasis
Neural network communication
Blood-brain barrier support
Regulation of CNS blood flow
CNS metabolism

Disease CNS Functions
Reactive astrogliosis and CNS inflammation
Neurodegenerative disease
Neuropsychiatric disease
Alexander disease and leukodystrophies
Multiple sclerosis and autoimmune inflammatory disorders
Infectious disease

Relevant Diseases

Alzheimer's Disease

Species

Human

Properties

Size

1 Vial: ≥ 1 x 10^6 cells/vial

Components

50ml iNeu Glial Base Medium
0.5ml iNeu Microglia Supplement A (100x)
0.5ml iNeu Microglia Supplement B (100x)
2 x 1ml iNeu Neural Supplement C (25X)

Tissue Source

Fibroblast

Age

<18

Mycoplasma Testing

The cell line has been screened using the Mycoplasma Detection Kit to confirm the absence of Mycoplasma contamination.

Shipping

Dry ice.

Storage

Liquid Nitrogen

Research Use Only

For research use only

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Target Details

Target

APOE

Official Name

CACNA1C

Alternative Names

Calcium Voltage-Gated Channel Subunit Alpha1 C; Calcium Channel; L Type; Alpha-1 Polypeptide; Isoform 1; Cardiac Muscle; Calcium Channel; Voltage-Dependent; L Type; Alpha 1C Subunit; CACNL1A1; CCHL1A1; CACH2; CACN2; Voltage-Gated L-Type Calcium Channel Cav1.2 Alpha 1 Subunit; Splice Variant 10*; Calcium Channel; Cardic Dihydropyridine-Sensitive; Alpha-1 Subunit;

Donor Information