NeuroMab™ Anti-BACE1 Antibody(NRP-0422-P1007)

Product Overview

Description

The antibody specifically binds to the human BACE1 protein, and can be useded for inhibiting amyloid-β formation and/or aggregation, inhibiting amyloid plaque formation, and treating neurodegenerative diseases.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

Inhib; WB; In Vitro; In Vivo

Application Notes

BACE1

Relevant Diseases

Alzheimer's Disease

Product Properties

Preservatives

BSA Free

Concentration

1mg/mL

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

BACE1

Official Name

BACE1

Full Name

Beta-Secretase 1

Alternative Names

Beta-Secretase 1; Membrane-Associated Aspartic Protease 2; Beta-Site APP Cleaving Enzyme 1; Beta-Site APP-Cleaving Enzyme; Aspartyl Protease 2; EC 3.4.23.46; Memapsin-2; Asp 2; BACE; ASP2;

Gene ID

23621 (Human); 23821 (Mouse); 29392 (Rat)

Uniprot ID

P56817 (Human); P56818 (Mouse); P56819 (Rat)

Product Pictures

FuncS

Figure 1 shows the results of the GALR2 filtration assay.

Membrane preparations from A9 cells engineered to overexpress GALR2 were incubated with 125I-labeled human galanin and mouse anti-galanin hybridoma supernatants and harvested onto GF/B Unifilter plates. Twenty-one hybridomas were able to inhibit the binding of human galanin to GALR2.