NeuroMab™ Anti-BACE1 BBB Shuttle Antibody(NRZP-1022-ZP3682)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; In Vitro; In Vivo; Inhib

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

BACE1

Official Name

BACE1

Full Name

Beta-Secretase 1

Alternative Names

Beta-Secretase 1; Membrane-Associated Aspartic Protease 2; Beta-Site APP Cleaving Enzyme 1; Beta-Site APP-Cleaving Enzyme; Aspartyl Protease 2; EC 3.4.23.46; Memapsin-2; Asp 2; BACE; ASP2;

Product Pictures

ELISA

Figure 1 depicts the results of experiments on recombinant amyloid precursor protein (APP) processing in 293-HEK cells using various anti-BACE1 antibodies (LC6, LC9, YW412.8, YW412.8.30, YW412.8.31, and YW412.8.51)An IgG antibody (Xolair®) that does not bind BACE1 was used as a control.

ELISA

Figure 2 provides a graph comparing the results of an ELISA comparing the competitive binding of the YW412.8 anti-BACE1 antibody to itself, another anti-BACE1 antibody (LC6), the active site BACE1 binding peptide (OM99-2), and the exosite BACE1 binding Show. Peptide (BMS1).

Publications