NeuroMab™ Anti-CXCL10 BBB Shuttle Antibody(NRZP-1022-ZP3431)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Isotype

IgG

Applications

WB; ELISA; IHC; Inhib; In Vitro; In Vivo

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

CXCL10

Official Name

CXCL10

Full Name

chemokine (C-X-C motif) ligand 10

Alternative Names

gIP-10; INP10; 10 kDa interferon gamma-induced protein; IP-10; C-X-C motif chemokine 10; 1-73; Small-inducible cytokine B10; IFI10; Gamma-IP10; SCYB10; crg-2; C7; mob-1

Product Pictures

FuncS

Figure 1 shows the efficacy of IP10.1 (6A1) and IP10.44 (18G2) antibody surrogates in two different colitis models.

FuncS

Figure 2 CD40-induced colitis shows the efficacy of IP10.1 (6A1) and IP10.44 (18G2) antibody surrogates in two different models of colitis.

FuncS

Figure 3 Reduction of circulating levels of cytokines, IP10.1 (which is a graph showing the activity of an antibody surrogate to 6A1 ) and IP10.44 (18G2) in a CD40-induced colitis model.

Publications