NeuroMab™ Anti-CXCL10 BBB Shuttle Antibody(NRZP-1022-ZP3439)
[CAT#: NRZP-1022-ZP3439]
- Host Species:
- Human
- Species Reactivity:
- Human; Mouse; Cynomolgus Monkey
- Applications:
- WB; ELISA; IHC; Neut; In Vitro; In Vivo
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Immunogen
Mature protein human IP-10 (hIP10) (NM001565)
Species Reactivity
Human; Mouse; Cynomolgus Monkey
Clonality
Monoclonal
Host Species
Human
Isotype
IgG
Applications
WB; ELISA; IHC; Neut; In Vitro; In Vivo
Relevant Diseases
Neuroinflammation
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
CXCL10
Official Name
CXCL10
Full Name
chemokine (C-X-C motif) ligand 10
Alternative Names
gIP-10; INP10; 10 kDa interferon gamma-induced protein; IP-10; C-X-C motif chemokine 10; 1-73; Small-inducible cytokine B10; IFI10; Gamma-IP10; SCYB10; crg-2; C7; mob-1
Product Pictures
ELISA
Figure 1 depicts the affinity of antibody NI-0801 for hIP-10.
ELISA
Figure 2 is a graph depicting the cross-reactivity of the NI-0801 antibody with IP-10 and other human chemokines from various species.
FuncS
Figure 3 depicts the ability of recombinant hITACs, hMIG and hIP-10 to induce cell chemotaxis of hCXCR3 expressing L1.2 cells.
Neut
Figure 4 depicts the ability of the NI-0801 antibody to neutralize the activity of these chemokines.
Neut
Figure 5 is a graph depicting the neutralization potential of NI-0801 against IP-10 from various species.
FuncS
Figure 6 is a graph depicting the ability of the NI-0801 antibody to bind a mutant form of rabbit IP-10.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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