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Creative Biolabs
Product

NeuroMab™ Anti- GluN3A/NR3A BBB Shuttle Antibody, Clone N416/40

[CAT#: NRZP-0423-ZP153]

Species Reactivity:
Mouse; Rat
Applications:
WB; IHC; ICC

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Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GRIN3A BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 58-87 or 152-176 (extracellular N-terminus) of mouse GluN3A (also known as Ionotropic glutamate receptor 3A, N-methyl-D-aspartate receptor subtype 3A, Glutamate receptor chi-1, NMDAR3A, NMDAR-L, NMDAR-L1, NR3A, Grin3A and KIAA1973, accession number A2AIR5)
Rat: 93% or 100% identity (28/30 or 25/25 amino acids identical)
Human: 83% or 96% identity (25/30 or 24/25 amino acids identical)
100% identity with Short isoform
<50% identity with GluN3B/NR3B and other GluN/NMDA receptors

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N416/40

Applications

WB; IHC; ICC

Conjugation

Unconjugated
Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.
Target

Target

GRIN3A

Official Name

GRIN3A

Full Name

GluN3A/NR3A glutamate receptor

Alternative Names

GRIN3A; GluN3A; NMDAR-L; NR3A; glutamate ionotropic receptor NMDA type subunit 3A; NMDAR3A

Uniprot ID

A2AIR5
Product Pictures
IB

Fig. 1 Immunoblot against crude membranes from neonatal or adult rat brain (RBM) and extracts of COS cells transiently transfected with untagged GluN3A/NR3A or Kv2.1 plasmid probed with N416/40 (left) or K35/40 (right) TC supe.

IF

Fig. 2 Immunofluorescence staining of permeabilized (left) and unpermerabilized (right) COS cells transiently transfected with GFPtagged GluN3A/NR3a and GluN1/NR1 plasmids with N416/40 (red).

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