NeuroMab™ Anti-HMGB1 Antibody(NRP-0422-P1784)

Product Overview

Description

The antibody screened from human Fab phage display library, and specifically binds HMG1 with high affinity. The high affinity antibody is a diagnostic antibody useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Applications

ELISA; Inhib; In Vitro; In Vivo

Relevant Diseases

Neuroinflammation

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

HMGB1

Official Name

HMGB1

Full Name

High-mobility group box 1

Alternative Names

HMGB1; HMG1; HMG3; SBP-1; HMG-1; high mobility group box 1

Gene ID

3146(Human); 100862258(Mouse); 25459(Rat)

Uniprot ID

P09429(Human); P63158(Mouse); P63159(Rat)

Product Pictures

ELISA

Figure 1 Binding kinetics and specificity of human anti-HMG1 antibodies.

HMG1 capture ELISA binding curves of several human anti-HMG1 antibodies demonstrate that these antibodies have different affinities for recombinant HMG1 produced in E. coli.