NeuroMab™ Anti-SOD1 BBB Shuttle Antibody(NRZP-1022-ZP2571)

Fig.1 results from SOD1-specific antibodies binding to various SOD1 proteins as determined by ELISA.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates from PDAPP mouse brain tissue. IgG was used as a negative control in this experiment because it is unable to bind Aβ and therefore cannot induce phagocytosis.

Fig.2 immunoblots detecting the immunoprecipitation of various hSOD1 proteins expressed in human cells.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates from PDAPP mouse brain tissue. IgG was used as a negative control in this experiment because it is unable to bind Aβ and therefore cannot induce phagocytosis.

Fig.3 shows images of immunohistochemistry staining of spinal cord tissue from mice transgenic for various hSOD1 proteins with ten SOD1 specific antibodies.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates from PDAPP mouse brain tissue. IgG was used as a negative control in this experiment because it is unable to bind Aβ and therefore cannot induce phagocytosis.

Fig.4 showing the average weight change of B6SJL-Tg(SOD1G93A)1Gur/J mice treated with monoclonal antibodies .

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates from PDAPP mouse brain tissue. IgG was used as a negative control in this experiment because it is unable to bind Aβ and therefore cannot induce phagocytosis.