NeuroMab™ Anti-Tau Antibody(NRP-0422-P1772)

Product Overview

Description

The monoclonal antibody binds selectively to pathological Tau, useful for treating tauopathies, neurodegenerative diseases associated with pathological aggregation of Tau.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse; Humanized

Applications

WB; DB; ELISA; IHC; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

Tau

Official Name

MAPT

Full Name

Tau

Alternative Names

CD14

Gene ID

4137(Human); 17762(Mouse); 29477(Rat)

Uniprot ID

P10636(Human); P10637(Mouse); P19332(Rat)

Product Pictures

Figure 1 shows Western blot analysis of HT7, mAb005, and mAb037 on rTg4510 and WT brain lysates.

Figure 2 shows Western blot analysis of HT7, mAb005, and mAb037 on AD and ND brain lysates.

Figure 3 shows Western blot analysis of sarcosyl soluble and insoluble fractions in AD brains by HT7, mAb005, and mAb037.

IHC

Figure 4 shows immunohistochemistry (IHC) of human brain sections with mAb005 (also known as RAA7) and mAb037 for the indicated brain regions and their disease status (ND vs AD), Braak stage (I-VI) and ID markers Dye on top.