Creative Biolabs

Mouse Anti-Human HSP90 alpha/beta Monoclonal Antibody (Clone L-S-522), Unconjugated

[CAT#: NAB2012451LS]

Anti-HSP90 alpha Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB; ICC; ELISA

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Description
Hsp90 is one of the most abundant molecular chaperones. It modulates the stability and transport of a diverse set of critical factors, including regulatory, metabolic, organizational, and signaling proteins. There are two major isoforms: α and β. In humans, the Hsp90β isoform is constitutively expressed, whereas the Hsp90α isoform is expressed under stress conditions. The Hsp90 dimer acts in concert with other chaperones and is regulated by a number of co-chaperones/accessory proteins. Upregulation of Hsp90 is associated with tumor progression, invasion and formation of metastases, and development of drug resistance. Therefore Hsp90 has emerged as an important target for cancer treatment.
Immunogen
Amino acids 291-304 of human HSP90α and β
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG
Clone Number
L-S-522
Applications
WB; ICC; ELISA
Application Notes
WB (0.125-1.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.
Concentration
1.0 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
HSP90 alpha
Official Name
Hsp90
Full Name
Heat shock protein 90
Alternative Names
HATPase
Gene ID
3326(Human); 15516(Mouse); 301252(Rat)
Uniprot ID
P08238(Human); P11499(Mouse); P34058(Rat)
1. Barrott JJ, et al. 2013. FEBS J. 280:1381.
2. Gorska M, et al. 2012. Front. Biosci. (Landmark Ed) 17:2269.
3. Barginear MF, et al. 2008. Curr. Cancer Drug Targets. 8:522.
4. Arya R, et al. 2007. J. Biosci. 32:595.
5. Neckers L, et al. 2003. Curr. Opin. Oncol. 15:419.
6. Nemoto T, et al. 1997. J. Biol. Chem. 272: 26179.
For Research Use Only. Not For Clinical Use.
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