NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody, Clone NR51P
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- DB; ELISA; FC; IHC; In Vitro; Cyt; In Vivo
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Fig.1 Alpha-synuclein staining in brain stem of an alpha-synuclein[A30P]-transgenic mouse.
Fresh frozen 10 μm sagittal brain sections; 40× magnification; all images at identical illumination conditions; arrowheads indicate Lewy neurite-like inclusions.
Fig.2 Staining of antibodies 0017 and 0018 in human brain cortex of a Parkinson's Disease patient.
(A), an Alzheimer's Disease patient with Parkinson's Disease comorbidity (B) and progressive supranuclear palsy (PSP, tauopathy) (C); arrow: Lewy-body like inclusions; arrowhead: Lewy neurite-like inclusions.
Fig.3 Cellular toxicity of conditioned media from recombinant alpha-synuclein from SHSY5Y cells on LUHMES cells.
(A), an Alzheimer's Disease patient with Parkinson's Disease comorbidity (B) and progressive supranuclear palsy (PSP, tauopathy) (C); arrow: Lewy-body like inclusions; arrowhead: Lewy neurite-like inclusions.
Fig.4 The antibody is able to immunodeplete alpha-synuclein oligomers from extracellular media and thereby these antibodies reduce toxicity of alpha-synuclein oligomers.
(A), an Alzheimer's Disease patient with Parkinson's Disease comorbidity (B) and progressive supranuclear palsy (PSP, tauopathy) (C); arrow: Lewy-body like inclusions; arrowhead: Lewy neurite-like inclusions.
Fig.5 Confocal microscopy analysis of immunohistochemically analyzed cryosections of Parkinson's Disease patient's brain sections (identical setting for all images).
(A) antibody 0017, (B) antibody 0018.
