NeuroMab™ Anti-Apo E BBB Shuttle Antibody, Clone 15G8
[CAT#: NRZP-1022-ZP3634]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; IP
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1k
Clone Number
15G8
Applications
WB; IP
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
Apo E
Official Name
APOE
Full Name
Apolipoprotein E
Alternative Names
APOE; AD2; APO-E; LDLCQ5; LPG; apolipoprotein E; ApoE4
Product Pictures
IP
Figure 1 shows the immunoprecipitation blots of full-length ApoE3, full-length ApoE4, ApoE3(1-272) and ApoE4(1-272).
WB
Figure 2 shows the results from wild-type mice ("wt"), apoE knockout mice ("KO"), and transgenic mice expressing human ApoE knock-in (E2, E3, and E4 strains) and human amyloid-β. Western blot of tissue lysates using mAbs 12C12 (left panel), 15E10 (middle panel) and 15G8 (right panel).
Kits
Neural Antibodies
Neural Cell Lines
Neural Genes
For Research Use Only. Not For Clinical Use.
