Product
NeuroMab™ Anti-SAP97 scaffold protein BBB Shuttle Antibody, Clone K64/15
[CAT#: NRZP-0423-ZP376]
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IHC; IP; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SAP97 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 1-104 (N-terminus) of rat SAP97 (also known as synapse-associated protein 97 and disks large homolog 1, accession number Q62696)
Human: 84% identity (87/104 amino acids identical)
Mouse: 90% identity (94/104 amino acids identical)
Human: 84% identity (87/104 amino acids identical)
Mouse: 90% identity (94/104 amino acids identical)
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Mouse; Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
K64/15
Applications
WB; IHC; IP; ICC
Application Notes
No crossreactivity against PSD-95, Chapsyn-110 and SAP102 expressed in transfected cells
Research Areas
Scaffolds
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
SAP97
Official Name
DLG1
Full Name
SAP97
Alternative Names
DLG1; DLGH1; SAP-97; SAP97; dJ1061C18.1.1; hdlg; B130052P05Rik; E-dlg/SAP97; mKIAA4187; discs large homolog 1; scribble cell polarity complex component; discs large MAGUK scaffold protein 1
Uniprot ID
Q62696
Product Pictures
IB
Fig. 1 Adult rat brain membrane immunoblot.
IB
Fig. 2 Immunoblot versus brain lysates from SAP97 wild-type (WT), knockout (KO) and heterozygous (Het) adult mice using K64/15 pure at 1µg/mL
IHC
Fig. 3 Adult rat hippocampus immunohistochemistry.
IB
Fig. 4 Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)], and hippocampus [HBM(H)].
Publications
Publications (0)
Neural Antibodies
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
