NeuroMab™ Anti-SAP97 scaffold protein BBB Shuttle Antibody, Clone K64/15

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SAP97 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-104 (N-terminus) of rat SAP97 (also known as synapse-associated protein 97 and disks large homolog 1, accession number Q62696)
Human: 84% identity (87/104 amino acids identical)
Mouse: 90% identity (94/104 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

K64/15

Applications

WB; IHC; IP; ICC

Application Notes

No crossreactivity against PSD-95, Chapsyn-110 and SAP102 expressed in transfected cells

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

SAP97

Official Name

DLG1

Full Name

SAP97

Alternative Names

DLG1; DLGH1; SAP-97; SAP97; dJ1061C18.1.1; hdlg; B130052P05Rik; E-dlg/SAP97; mKIAA4187; discs large homolog 1; scribble cell polarity complex component; discs large MAGUK scaffold protein 1

Uniprot ID

Q62696

Product Pictures

Fig. 1 Adult rat brain membrane immunoblot.

Fig. 2 Immunoblot versus brain lysates from SAP97 wild-type (WT), knockout (KO) and heterozygous (Het) adult mice using K64/15 pure at 1µg/mL

IHC

Fig. 3 Adult rat hippocampus immunohistochemistry.

Fig. 4 Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)], and hippocampus [HBM(H)].

Publications