Mouse Anti-Rat SAP97 Monoclonal Antibody (CBP3892)

Product Overview

Description

SAP97-Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.

Immunogen

This monoclonal antibody was raised against a fusion protein corresponding to amino acids 1-104 (N-terminus) of rat SAP97 protein.

Species Reactivity

Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP3892

Applications

Application Notes

WB (2.0- 10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.

Concentration

1.0 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

SAP97

Official Name

DLG1

Full Name

Discoid homolog 1

Alternative Names

DLG1; DLGH1; SAP-97; SAP97; dJ1061C18.1.1; hdlg; B130052P05Rik; E-dlg/SAP97; mKIAA4187; discs large homolog 1; scribble cell polarity complex component; discs large MAGUK scaffold protein 1