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Creative Biolabs

NeuroMab™ Anti-SOD1 BBB Shuttle Antibody(NRZP-1022-ZP2576)

[CAT#: NRZP-1022-ZP2576]

Host Species:
Camelid
Species Reactivity:
Human
Applications:
WB; IP; Block; Inhib; In Vitro; In Vivo

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Camelid

Applications

WB; IP; Block; Inhib; In Vitro; In Vivo

Relevant Diseases

Amyotrophic Lateral Sclerosis
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

SOD1

Official Name

SOD1

Full Name

superoxide dismutase 1

Alternative Names

SOD1; ALS; ALS1; HEL-S-44; IPOA; SOD; hSod1; homodimer; superoxide dismutase 1; soluble; superoxide dismutase 1; STAHP
Product Pictures
WB

Fig.1 Western Dot Blot showing the binding of nanobodies to immobilized recombinant SOD1.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates from PDAPP mouse brain tissue. IgG was used as a negative control in this experiment because it is unable to bind Aβ and therefore cannot induce phagocytosis.

FuncS

Fig.2 SOD1 nanobodies reduce SOD1 aggregation in HeLa cells.

Expression of HA-tag Nb and SOD1-CFP in HeLa cells

FuncS

Fig.3 The SOD1 nanobody reduces SOD activity.

When the SOD1 nanobody is added to the cell medium, the SOD activity is decreased. Read-outs are OD values, inversely correlated with SOD activity.

FuncS

Fig.4 The survival and disease onset are increased in treated hSOD1G93A mice.

When the SOD1 nanobody is added to the cell medium, the SOD activity is decreased. Read-outs are OD values, inversely correlated with SOD activity.

FuncS

Fig.5 The SOD1 nanobody rescues MN death.

The number of small MN, but not of big MN, was increased at P145 in mice treated with SOD1 nanobody from P60.

WB

Fig.6 The SOD1 nanobody recognizes neurotoxic forms of SOD1.

The number of small MN, but not of big MN, was increased at P145 in mice treated with SOD1 nanobody from P60.

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