NeuroMab™ Anti-Tau BBB Shuttle Antibody(NRZP-1022-ZP3089)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Immunogen

full-length human tau (longest isoform. 2N4R; 441 amino acids )

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

WB; ELISA; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

Tau

Official Name

MAPT

Full Name

Tau Protein

Alternative Names

MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins; tau-40

Product Pictures

FuncS

Figure 1. Graph illustrating counts of beads coupled to ADx202; Y-axis represents counts and X-axis represents diameter in µm.

FuncS

Figure 2. Graph illustrating counts of beads coupled to Tau-5; Y-axis represents counts and X-axis represents diameter in μm.

FuncS

Figure 3: Graph representing MAGPIX median fluorescence intensity

(MFI) measurement of beads coupled with ADx202 and Tau -5 using a phycoerythrin- labeled anti-mouse IgG detection antibody (anti-mouse-PE). The X-axis represents the concentration of the ph ycoery th rin-1 abel ed anti-mouse IgG detection antibody: the Y-axis represents the MFI measurement. These data illustrate that the amount of antibody coupled per bead is higher for Tau5 than for ADx202.

FuncS

Figure 4: Graph representing MAGPIX median fluorescence intensity (MFI) measurements of beads conjugated to ADx202 and Tau-5 using the antigen human tau-441.

The X-axis represents the concentration of rPeptide441 in pg/mL: the Y-axis represents the MFI measurement. These data illustrate that ADx202 captures rPeptide tau441 more efficiently then Tau5.

Publications