NeuroMab™ Anti-Tau BBB Shuttle Antibody(NRZP-1022-ZP3146)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Immunogen

recombinant human tau protein, isoform 2N4R.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

llama

Applications

WB; ELISA; IHC; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

Tau

Official Name

MAPT

Full Name

Tau Protein

Alternative Names

MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins; tau-40

Product Pictures

SDS-PAGE

Figure 1 shows the protein purity analysis of selected anti-Tau sdAb phage clones.

The figure shows Commassie-stained SDS-PAGE of the expressed and purified sdAb in pSJF2 expression vector. Lane 1, molecular weight markers; lane 2, a non-specific VH; lane 3, 3Tau15 (Tau15); lane 4, a non-specific VH; lane 5, 7Tau81 (Tau81); lane 6, a non-specific VH (˜5 μg/lane). The sdAbs ran at their expected molecular weights.

ELISA

Figure 2 is a bar graph showing protein ELISA results. Tau15 and Tau81 show strong signals.

FuncS

Figure 3 shows the size exclusion chromatogram of purified sdAb Tau81 (Figure 4B) injected at a concentration of approximately 20 μM.

FuncS

Figure 4 shows the thermal unfolding curves of Tau15 and Tau81 at neutral pH (7.3). Measure sdAb unfolding using a circular dichroism spectrometer using a protein concentration of 50 µg/mL.

Publications