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Creative Biolabs

NeuroMab™ Anti-TDP43 Antibody(NRP-0422-P708)

[CAT#: NRP-0422-P708]

A functional antibody raised against Human TDP43.

Host Species:
Mouse
Species Reactivity:
Human
Applications:
ELISA; IHC; ICC; Inhib; In Vitro; In Vivo

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Product Overview

Description

The mouse monoclonal antibody binds to the N-terminal epitope of TDP-43.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; IHC; ICC; Inhib; In Vitro; In Vivo

Relevant Diseases

Amyotrophic Lateral Sclerosis
Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only
Target

Target

TDP43

Official Name

TDP-43

Full Name

TAR DNA binding protein

Alternative Names

TDP-43; TAR DNA binding protein

Gene ID

23435(Human); 230908(Mouse); 298648(Rat)

Uniprot ID

Q13148(Human); Q921F2(Mouse)
Product Pictures
IF

Figure 1 shows that the 3F11 mouse monoclonal antibody directed against the disease-associated N-terminal TDP43 epitope does not react with physiological stress granules.

Immunofluorescent staining of human TDP-43 and TDP-43 oligomers in brain sections of wild-type and 6- and 12-month-old TDP-43 Tg+/+ transgenic mice. Cells with anti-TDP oligomer staining, TDP-43 staining, and DAPI staining are shown (scale bar, 100 μm). Closed regions are presented at higher magnification in the last column (scale bar, 25 μm).

Block

Figure 2 shows that antibodies block delivery of misfolded TDP-43 in HEK293 cells.

Immunofluorescent staining of human TDP-43 and TDP-43 oligomers in brain sections of wild-type and 6- and 12-month-old TDP-43 Tg+/+ transgenic mice. Cells with anti-TDP oligomer staining, TDP-43 staining, and DAPI staining are shown (scale bar, 100 μm). Closed regions are presented at higher magnification in the last column (scale bar, 25 μm).

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