Creative Biolabs

Rat Anti-MBP Monoclonal Antibody (W0011), Unconjugated

[CAT#: NAB2007FY253]

Rat Monoclonal [W0011] to MBP

Host Species:
Rat
Species Reactivity:
Bovine; Mouse; Mammals; Rabbit; Rat; Sheep; Porcine; Guinea Porcine; Human; Chicken
Applications:
ELISA; IF; WB; RIA

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Description
The rat anti-MBP antibody can recognize myelin basic protein of many species. The rat anti-MBP antibody reacts weakly with peptides terminated at Phe 91 (where the 91-92 Phe-Phe bond is broken). Just like the complete MBP, synthetic peptide 82-99 reacts very well with Rat anti-MBP antibody. Further epitope analysis showed binding to the region defined by amino acids 82-87 (DENPVV).
Immunogen
Bovine MBP.
Species Reactivity
Bovine; Mouse; Mammals; Rabbit; Rat; Sheep; Porcine; Guinea Porcine; Human; Chicken
Clonality
Monoclonal
Host Species
Rat
Isotype
IgG2a
Clone Number
W0011
Applications
ELISA; IF; WB; RIA
Relevant Diseases
Neurological Disorders
Research Areas
Growth and Development
Conjugation
Unconjugated
Form
Tissue Culture Supernatant-liquid
Formulation
Tissue Culture Supernatant-0.1M TRIS
0.1% Sodium Azide
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store at +4°C or at -20°C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody.
Should this product contain a precipitate we recommend micr°Centrifugation before use.
Target
Myelin Basic Protein
Official Name
MBP
Full Name
Myelin basic protein
Alternative Names
MBP; entrez:4155; myelin basic protein; Myelin basic protein; Myelin_BP; IPR000548
Gene ID
4155(Human); 17196(Mouse); 24547(Rat)
Uniprot ID
P02686(Human); P04370(Mouse); P02688(Rat)
1. Homchaudhuri L et al. (2009) Influence of membrane surface charge and post-translational modifications to myelin basic protein on its ability to tether the Fyn-SH3 domain to a membrane in vitro.
2. Pohl, H.B. et al. (2011) Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage.
3. Laursen, L.S. et al. (2011) Translation of myelin basic protein mRNA in oligodendrocytes is regulated by integrin activation and hnRNP-K.
4. Relucio, J. et al. (2009) Laminin alters fyn regulatory mechanisms and promotes oligodendrocyte development.
Neural Genes
Neural Proteins & Peptides
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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