Rat Anti-MBP Monoclonal Antibody (CBP1569)

Product Overview

Description

The rat anti-MBP antibody can recognize myelin basic protein of many species. The rat anti-MBP antibody reacts weakly with peptides terminated at Phe 91 (where the 91-92 Phe-Phe bond is broken). Just like the complete MBP, synthetic peptide 82-99 reacts very well with Rat anti-MBP antibody. Further epitope analysis showed binding to the region defined by amino acids 82-87 (DENPVV).

Immunogen

Bovine MBP.

Species Reactivity

Bovine; Mouse; Mammals; Rabbit; Rat; Sheep; Porcine; Guinea Porcine; Human; Chicken

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2a

Clone Number

CBP1569

Applications

ELISA; IF; WB; RIA

Research Areas

Growth and Development

Conjugation

Unconjugated

Product Properties

Form

Tissue Culture Supernatant-liquid

Formulation

Tissue Culture Supernatant-0.1M TRIS
0.1% Sodium Azide

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody.
Should this product contain a precipitate we recommend micr°Centrifugation before use.

Target

Myelin Basic Protein

Official Name

MBP

Full Name

Myelin basic protein

Alternative Names

MBP; entrez:4155; myelin basic protein; Myelin basic protein; Myelin_BP; IPR000548

Gene ID

4155(Human); 17196(Mouse); 24547(Rat)

Uniprot ID

P02686(Human); P04370(Mouse); P02688(Rat)

References

1. Homchaudhuri L et al. (2009) Influence of membrane surface charge and post-translational modifications to myelin basic protein on its ability to tether the Fyn-SH3 domain to a membrane in vitro.
2. Pohl, H.B. et al. (2011) Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage.
3. Laursen, L.S. et al. (2011) Translation of myelin basic protein mRNA in oligodendrocytes is regulated by integrin activation and hnRNP-K.
4. Relucio, J. et al. (2009) Laminin alters fyn regulatory mechanisms and promotes oligodendrocyte development.

Publications