Creative Biolabs

Rat Anti-Mouse Tau 1-100 Monoclonal Antibody (Clone 3B3C32)

[CAT#: NAB2010621LS]

Anti Apo E Monoclonal Antibody

Host Species:
Rat
Species Reactivity:
Mouse
Applications:
WB

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Description
Apo-E is a class of apolipoprotein primarily synthesized in the liver, but is also found in other tissues such as brain, kidneys, and spleen. Apo-E is a protein component of serum chylomicron and lipoprotein particles, playing essential roles in cholesterol transportation, homeostasis, and metabolism. The expression of Apo-E is induced by cholesterol-rich diets and hyperlipoproteinemia. In the central nervous system, Apo-E is produced by astrocytes and microglia. The Apo-E-containing lipoprotein particles play important functions in brain injury repair, neurogenesis, and synaptic plasticity. Apo-E has been found to be involved in the regulation of amyloid-β aggregation and clearance. Genetic polymorphisms of Apo-E are associated with neuron degenerative disorders including Alzheimer's disease.
Immunogen
Full length mouse Apo-E recombinant protein expressed in E. coli.
Species Reactivity
Mouse
Clonality
Monoclonal
Host Species
Rat
Isotype
IgG2a, κ
Clone Number
3B3C32
Applications
WB
Application Notes
WB (0.5-2.5 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
Unconjugated
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.10% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
The antibody solution should be stored undiluted between 2°C and 8°C.
Handling Advice
Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Apo E
Official Name
APOE
Full Name
Apolipoprotein E
Alternative Names
APOE; AD2; APO-E; LDLCQ5; LPG; apolipoprotein E; ApoE4
Gene ID
348 (Human); 11816 (Mouse)
Uniprot ID
P02649 (Human); P08226 (Mouse)
1. Hayes EM, et al. 2014. Front Immunol. 5:537.
2. Kim J, et al. 2014. Mol. Cells 37:767.
3. Verghese PB, et al. 2013. Proc. Natl. Acad. Sci. USA 110:E1807.
4. Mahley RW, et al. 2012. Neuron 76:871.
5. Holtzman DM, et al. 2012. Cold Spring Harb. Perspect. Med. 2:a006312.
6. Zhang HL, et al. 2010. Clin. Dev. Immunol. 2010:186813.
Neural Genes
Neural Antibodies
Kits
Neural Cell Lines
Neural Proteins & Peptides
For Research Use Only. Not For Clinical Use.
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