NeuroMab™ Anti-CD4 BBB Shuttle Antibody(NRZP-1022-ZP3724)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Applications

ELISA; ADCC; Cyt; CDC

Relevant Diseases

Meningitis

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

CD4

Official Name

CD4

Alternative Names

CD4; CD4mut; CD4 molecule

Product Pictures

ELISA

Figure 1 shows the reactivity of various anti-CD4 antibodies in a binding ELISA.

The horizontal axis represents the concentration of each antibody, and the vertical axis represents the binding activity of each antibody. The reactivity of each antibody against recombinant human CD4 is shown. Dotted line △ represents monoclonal antibody 6G5-1, solid line △ represents anti-CD4 human antibody 6G5-P, ▴ represents anti-CD4 human antibody 6G5-113F, ● represents anti-CD4 chimeric antibody KM4045, ▪ represents anti-CD4 chimeric antibody KM4046, □ represents anti-CD4 chimeric antibody KM4047, dotted line x represents anti-CD4 chimeric antibody KM4048, solid line x represents anti-CD4 chimeric antibody KM4049.

Publications