Mouse Anti-Human CD55 Monoclonal Antibody (CBP2338)

Product Overview

Description

CD55, also known as the complement decay-accelerating factor, is a protein that regulates the complement system on the cell surface. CD55 recognizes the complement C4b and C3b fragments that are generated during C3 and C4 activation, and indirectly blocks the formation of the membrane attack complex. CD55 has also been shown to be a ligand for the seven-span transmembrane receptor CD97. Interaction between CD55 and CD97 has been suggested to play an important role in the pathogenesis of multiple sclerosis and rheumatoid arthritis.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP2338

Applications

WB; IHC-P

Application Notes

WB (0.5-10 µg/mL); IHC-P (2.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD55

Official Name

CD55

Full Name

Complement decay-accelerating factor

Alternative Names

CD55; CR; CROM; DAF; TC; CD55 molecule (Cromer blood group); CHAPLE

Gene ID

1604 (Human); 13137 (Mouse)

Uniprot ID

P08174 (Human); Q61476 (Mouse)

References

1. Dho SH, et al. 2018. Immune Netw. 18(1):e11
2. Nowicki B, et al. 2013. Adv Exp Med Biol. 735:83
3. Piccoli AK, et al. 2011. Rev Bras Reumatol. 51(5):503

Publications