NeuroMab™ Mouse Anti-TDP43 Monoclonal Antibody (CBP2545)
[CAT#: NAB2007FY927]
Mouse Monoclonal [2E2-D3] to TDP43
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- IF; IHC-P; WB
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Mouse anti-human TDP43 antibody, recognizes human TAR DNA binding protein 43, also known as TDP43. TPD43 is a transcription and splicing regulator of 414 amino acids ~ 45 kDa. Two isoforms of TDP43 produced by alternative splicing have been described. Mouse anti-human TDP43 antibody, clone 2E2-D3, binds to canonical isoform 1. The binding to truncated isotype 2 is not yet clear, which lacks a significant portion of the immunogenic sequence used to generate clone 2E2-D3. Mutations in the TDP43 gene can lead to the development of amyotrophic lateral sclerosis 10 (ALS10), a neurodegenerative disease that affects the upper motor neurons of the brain and the lower motor neurons of the brain stem and spinal cord, resulting in fatalities paralysis.
Immunogen
A recombinant protein corresponding to amino acids 1-261 of human TDP43.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1
Clone Number
CBP2545
Applications
IF; IHC-P; WB
Application Notes
IF: 0.1-10 ug/ml
IHC-P: 0.1-10 ug/ml
WB: 0.1-10 ug/ml
IHC-P: 0.1-10 ug/ml
WB: 0.1-10 ug/ml
Relevant Diseases
Amyotrophic Lateral Sclerosis; Frontotemporal Dementia
Conjugation
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1857
Product Properties
Form
Liquid
Formulation
PBS
Preservatives
BSA free
Purification
Affinity chromatography
Endotoxin Level
Low Endotoxin
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store at -20°C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Publications
Publications (0)
Neural Antibodies
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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