Cortical Neuron related Assay Service for Drug Discovery
At Creative Biolabs, our newly launched human induced pluripotent stem cell (iPSC) derived cortical neurons provide a powerful platform for studying neurological diseases, opening new opportunities for drug discovery, target identification, and toxicity testing. We are dedicated to offering our clients the highest standards of scientific practice and customer service. To learn more about our products and services, submit a project inquiry or request pricing, please contact us.
Introduction
Using iPSC-differentiated neurons has many advantages. iPSC-derived neurons carry the genetic background of their donors, allowing for accurate simulation of disease states and ensuring the model remains close to in vivo conditions. In addition, iPSC technology is faster, more flexible, and more replicable than similar studies using primary tissue, making it an excellent choice for drug discovery. Listed below are a few of our products for neuronal iPSCs.
iNeu™ Human Cortical Neuron Kit | Human iPS Cell Line (Alzheimer's Disease) |
Human iPS Cell Line (Parkinson's Disease) | Human iPS Cell Line (Amyotrophic Lateral Sclerosis) |
Cortical Neurons Drug Discovery Assay
- High-Throughput Screening (HTS)
High-throughput screening (HTS) is a crucial technique in the field of drug discovery and screening. HTS technology enables researchers to conduct many experiments in parallel through automated operating systems and detection instruments, significantly enhancing the efficiency of drug research and development. iPSC technology pairs beautifully with HTS due to its proliferative properties, closeness to in vivo conditions, and ability to mirror disease states. We are pleased to offer HTS using hiPSC-derived cortical neurons as a platform to enhance your drug screening research.
Assays | Descriptions |
Cell-based assays | These assays characterize the effects of a compound on the cellular level. For example, the MTT assay is used to measure cell viability, the LDH assay is employed to assess the cytotoxicity, and flow cytometry is utilized to analyze apoptosis. |
Biochemical assays | These assays examine the specific effects of compounds through the lenses of enzyme kinetics and binding efficiencies. Examples of this include the evaluation of pharmacological targets of GPCR receptors and enzymes, as well as pharmacological analysis of agonists and antagonists. |
High-content screening (HCS) | HTS technology can also be combined with high-content screening (HCS) technology to simultaneously detect multiple targets and multiple parameters at the single-cell level through live cell imaging, thereby providing a more comprehensive reflection of the physiological activity characteristics. The application of this technology is not limited to small molecule drug development, and is also a great choice for receptor-based drug screening research. |
Microelectrode arrays (MEAs) are a valuable tool for recording and measuring neuronal activity. This technology allows us to evaluate in real-time how neuronal activity behaves in an environmentally controlled environment. This assay is central to drug discovery in fields such as epilepsy and acts as a complement to other methods of drug screening by additionally filtering out compounds that cause negative electrical activity.
At Creative Biolabs, we offer a range of options for customizing cortical neuron drug discovery assays to meet your specific requirements. Furthermore, we provide high-quality materials, data, and insights to maximize the success of your project. Please do not hesitate to contact us to discuss your project plans in more detail.
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