Cortical Neurons Efficacy Assay

In recent years, human induced pluripotent stem cell (iPSC)-derived cortical neurons have provided a powerful platform for studying neurological diseases. As an expert in neuroscience, Creative Biolabs has established extensive collaborations with various research groups in the field. We have established diverse cell models and advanced technology platforms to help provide high-quality cortical neuron efficacy assay services to global customers.

Overview of Cortical Neurons

As we all know, the mammalian cerebral cortex coordinates sensory and motor information to enable animals to perform complex tasks. Neuronal communication in the cortex constitutes a highly complex network of neuronal connections. Cortical neurons contain two main subtypes: glutamatergic excitatory neurons and gamma-aminobutyric acid (GABA) inhibitory neurons. Cortical neurons are closely related to emotional, language, and motor functions. Therefore, cortical neurons are involved in a variety of neurological disorders, including Huntington's disease (HD), Alzheimer's disease (AD) and schizophrenia. Growing evidence suggests that the generation of human cortical neurons is critical for mechanistic studies of these diseases and offers new perspectives for drug development.

Cell Culture Models at Creative Biolabs

Relying on state-of-the-art facilities and advanced platforms, many cortical neurons related cell models are available at Creative Biolabs. Our models mainly include but are not limited to:

• Primary Neuronal Cell Culture Models
• Human iPSC Derived Neuronal Cell Culture Models
• AD In Vitro Models
• PD In Vitro Models
• ALS In Vitro Models

Cortical Neurons Efficacy Assay at Creative Biolabs

In vitro cortex cell culture systems are effective strategies for exploring new technologies in neurology. In addition, these systems occupy an important position in immunocytochemistry and drug screening studies. Furthermore, cortical neurons have been used to understand the mechanisms of neuronal plasticity. Most importantly, functional models of mature hiPSC cortical neurons have attracted considerable attention. By integrating microelectrode-array (MEA) technology, the system demonstrates the ability to model neurological diseases, suggesting that the model is useful for in vitro preclinical drug testing. At Creative Biolabs, our services include but are not limited to:

• Cell viability assay
• Neuroprotection assay
• Compound screening assay
• Drug testing assay

Fig.1 Applications of cell reprogramming. (McCaughey-Chapman & Connor, 2018)

Why Choose Us?

• Creative Biolabs generates human iPSC-derived cortical neurons that display physiological characteristics and form functional neuronal networks. Our cortical neurons can be maintained in culture for extended periods and cryopreserved at different stages of their differentiation.
• We developed phenotypic models of specific hiPSC-derived cortical neurons, revealing their application in disease modeling.
• At Creative Biolabs, we improve the relevance of in vitro screening of neuroprotective compounds by screening drug libraries with an improved model of adult cortical neurons.
• We co-culture cortical neurons with astrocytes and microglia to create more complex, robust and relevant cellular models for drug discovery in neurological diseases.

As a reputable neurological service provider, Creative Biolabs is willing to share expertise, select appropriate in vitro models, and collect reliable data to advance your progress in neurological disease research. If you have any difficulties in cortical neurons related projects, please contact us for help in time.

Reference

1. McCaughey-Chapman, A.; Connor, B. Human cortical neuron generation using cell reprogramming: a review of recent advances. Stem cells and development. 2018, 27(24): 1674-1692.