Central/Peripheral Neuronal Firing Assay Service

Central/peripheral neuronal firing assays are instrumental in monitoring neuronal activity, understanding neuronal firing patterns, applying predictive models, and confirming compound potency and efficacy. To learn more about our products and services, submit a project request, or request a quote, please contact us today.

What Can We Provide?

At Creative Biolabs, we have developed a platform for electrophysiological characterization of human iPSC-derived neuronal cells. We offer a range of protocols for differentiating human iPSCs into various cell types from the peripheral nervous system (PNS) and central nervous system (CNS), allowing for experimentation on your cell of interest. Additionally, we measure the electrical activity of these cells through our microelectrode arrays (MEAs) and patch clamp assay platforms.

Multielectrode Array (MEA) Platform

MEA has the capacity to record the electrical activity of neurons for a variety of applications, including electrical stimulation, drug testing, and the creation of disease models. It is capable of recording mean firing rate, burst duration, , and the network activity of neurons, thereby providing a holistic view of neuronal cultures. Moreover, MEA can be employed to record the spontaneous and evoked activity of neuronal populations over an extended period, thus enabling the assessment of the impact of compounds on neuronal function over extended periods of time.

Patch-Clamp Platform

Patch clamp technology can be employed to examine the dynamic attributes of individual ion channels, while whole-cell recording can also be utilized to investigate channel, receptor, and cellular electrical activity. Moreover, patch-clamp technology can be integrated with optical techniques, including voltage clamp fluorescence measurement and calcium imaging, to enhance the precision and resolution of the research.

Fig.1 Patch-clamp recording.

At Creative Biolabs, our central/peripheral neuron firing measurement service utilizes a combination of multi-electrode array and patch clamp recording technology to facilitate the collection of high-throughput data. Our team of experienced data processing experts then generates comprehensive reports to assist you in analyzing and deeply studying the coding mechanism and pathological changes of the nervous system. We invite you to contact us to discuss your project plan in detail.