Schwann Cell related Assay Service

Schwann cells (SCs) represent a significant class of glial cells within the peripheral nervous system (PNS). They are responsible for the formation of the myelin sheath surrounding nerve fibers and play a pivotal role in the processes of nerve regeneration and repair. At Creative Biolabs, we offer highly accurate and reliable Schwann Cell assays, tightly controlling our experiments to provide you with the best results possible. To learn more about our products and services, submit a project inquiry, or request a quote, please contact us today.

Schwann Cell Products

In vitro studies offer a great way to obtain cheap, fast, and replicable results for preclinical drug screenings and other research applications. Creative Biolabs offers a comprehensive range of primary Schwann cells, including mouse, rat, human, and iPSC-derived Schwann cell lines, to meet your research needs.

Schwann Cell Isolation Service

There are many methods for isolating Schwann cells, including monolayer cell culture, tissue block culture, enzyme digestion, immunoselection, magnetic cell sorting, etc. Considering your input, experimental needs, and laboratory conditions, our expert will select the perfect method for your study. We offer purification of Schwann cells from diverse sources, including rat, mouse, and human peripheral nerve tissue, and can cater the delivery of these cells to your needs.

Fig.1 Schwann Cell Isolation.¹

Schwann Cell Assays

• Schwann Cell Characterization

The characterization of Schwann cells typically employs a range of techniques, including immunofluorescence staining, Western blotting, PCR analysis, and transcriptomics. These methods are used to assess the expression of markers associated with differentiated cells and intermediate stages of differentiation.

• Co-culture of Schwann Cells and Primary Neurons

Schwann cell function can be assessed when co-cultured with primary neurons. While in co-culture, the secretion of neurotrophic factors, the ability to induce neurite outgrowth, align with neurites, and myelinate neurons can be assessed through ELISA, live-cell imaging, and other characterization methods. Increases in these measures indicate high Schwann cell function.

• Schwann Cells in Nerve Regeneration and Repair

Schwann cells play an important role in nerve regeneration and repair, particularly in the repair of peripheral nervous system injuries. However, newer research is investigating the application of Schwann cells in repair of the central nervous system and neural tissue engineering, providing new opportunities for nervous system regeneration.

At Creative Biolabs, our scientists are experts in the culture and testing of Schwann cells. We invite you to contact us to discuss your project plans in detail.

Reference

1. Monje, Paula V. "Schwann cell cultures: biology, technology and therapeutics." Cells 9.8 (2020): 1848. Distributed under Open Access license CC BY 4.0, without modification.