NeuroMab™ Anti-NOS1/nNOS BBB Shuttle Antibody, Clone L121/25

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-nNOS BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 350-720 of human NOS1 (also known as Brain nitric oxide synthase, Constitutive NOS, Neuronal NOS, Peptidyl-cysteine S-nitrosylase NOS1, NC-NOS, NOS type I, N-NOS, nNOS and BNOS, accession number P29475)
Rat: 98% identity (363/371 amino acids identical)
Mouse: 98% identity (362/370 amino acids identical)
>70% identity with NOS2/iNOS and NOS3/eNOS

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

L121/25

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

nNOS

Official Name

NOS1

Full Name

nNOS/NOS1

Alternative Names

NOS1; IHPS1; N-NOS; NC-NOS; NOS; bNOS; nNOS; nitric oxide synthase 1

Uniprot ID

P29475

Product Pictures

Fig. 1 Array tomography immunofluorescence volume reconstruction of 9 serial LRWhiteembedded 70 nm sections from adult mouse cortex layer 6 with L121/25 (green), rabbit Synapsin (red) and DAPI (blue).