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Creative Biolabs

NeuroMab™ Anti-SOD1 Antibody(NRP-0422-P658)

[CAT#: NRP-0422-P658]

A functional antibody raised against Human SOD1.

Host Species:
Camelid
Species Reactivity:
Human
Applications:
WB; IP; Block; Inhib; In Vitro; In Vivo

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Product Overview

Description

The single-domain antibody against SOD1 protein can be used for the treatment of amyotrophic lateral sclerosis (ALS) or the amelioration of symptoms associated with ALS.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Camelid

Applications

WB; IP; Block; Inhib; In Vitro; In Vivo

Relevant Diseases

Amyotrophic Lateral Sclerosis
Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only
Target

Target

SOD1

Official Name

SOD1

Full Name

superoxide dismutase 1

Alternative Names

SOD1; ALS; ALS1; HEL-S-44; IPOA; SOD; hSod1; homodimer; superoxide dismutase 1; soluble; superoxide dismutase 1; STAHP
Product Pictures
WB

Figure 1 Western Dot Blot showing the binding of Nanobodies to immobilized recombinant SOD1.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.

FuncS

Figure 2 SOD1 nanobody reduces SOD1 aggregation in HeLa cells.

Expression of HA-tag Nb and SOD1-CFP in HeLa cells

FuncS

Figure 3 SOD1 nanobody reduces SOD activity.

When SOD1 Nanobody was added to cell culture medium, SOD activity was reduced. The readout is the OD value, which correlates inversely with SOD activity.

FuncS

Figure 4 Increased survival and disease onset in treated hSOD1G93A mice.

When SOD1 Nanobody was added to cell culture medium, SOD activity was reduced. The readout is the OD value, which correlates inversely with SOD activity.

FuncS

Figure 5 SOD1 nanobody rescued MN death.

In mice treated with SOD1 Nanobody from P60, the number of small MNs increased at P145, but that of large MNs did not.

WB

Figure 6 SOD1 Nanobody recognizes the neurotoxic form of SOD1.

In mice treated with SOD1 Nanobody from P60, the number of small MNs increased at P145, but that of large MNs did not.

Publications

Publications (0)

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