NeuroMab™ Mouse Anti-Human β-Amyloid 17-24 Monoclonal Antibody (CBP4338)

Product Overview

Description

Aβ peptides are derived from amyloid precursor protein (APP) through sequential proteolytic cleavage of APP by β-secretases and γ-secretases generating diverse Aβ species. Aβ can aggregate to form soluble oligomeric species and insoluble fibrillar or amorphous assemblies. Some forms of the aggregated peptides are toxic to neurons.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP4338

Applications

IHC-P

Application Notes

IHC-P (1.0-5.0 μg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 2308

Product Properties

Form

Liquid

Formulation

This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.

Concentration

Batch Dependent

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

APP

Official Name

APP

Full Name

Amyloid Precursor Protein

Alternative Names

APP; AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; amyloid beta precursor protein; preA4

Gene ID

351 (Human); 11820 (Mouse); 54226 (Rat)

Uniprot ID

P05067 (Human); P12023 (Mouse); P08592 (Rat)

References

1. Puig KL, et al. 2012. Exp Gerontol. 48(7): 608.
2. Selkoe DJ, et al. 2016. EMBO Mol Med. 8(6):595.
3. Walsh DM, et a. 2007. J Neurochem. 101(5):1172.

Publications