Creative Biolabs

Mouse Anti-Human α-Synuclein Monoclonal Antibody (Clone L-S-514)Nitrated Antibody, Unconjugated

[CAT#: NAB2012885LS]

Anti-α-Synuclein Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC-P; ICC

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Description
α-synuclein is expressed principally in the nervous system. At least three isoforms of α-synuclein are produced through alternative splicing. The most common isoform is a 140 amino acid-long transcript. Other isoforms includes, a-synuclein-126, lacking residues 41-54; and α-synuclein-112, which lacks residues 103-130. α-synuclein's physiological role is poorly understood, but the protein has been implicated in regulating dopamine release and transport, synaptic vesicle clustering, and functioning as a SNARE-complex chaperone. α-synuclein fibrils are a major component of the intracellular Lewy bodies that are associated with Parkinson's disease, Lewy body dementia, and multiple system atrophy. α-synuclein is phosphorylated at low levels under normal physiological conditions whereas the majority of the protein is phosphorylated in Lewy bodies at S129.
Immunogen
Syn514 was raised using oxidized alpha-synuclein (α-synuclein) and recognizes its native and nitrated/oxidized forms.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1, κ
Clone Number
L-S-514
Applications
IHC-P; ICC
Application Notes
IHC-P (0.5-5.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Alpha Synuclein
Official Name
SNCA
Full Name
Alpha-synuclein
Alternative Names
CD14
Gene ID
6622 (Human); 20617 (Mouse)
Neural Antibodies
Neural Cell Lines
Kits
Neural Proteins & Peptides
Neural Genes
For Research Use Only. Not For Clinical Use.
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