Epilepsy and Seizures Related Research Tools

The epilepsy is a chronic neurological disorder in which clusters of nerve cells in the brain signal abnormally and cause seizures. The syndromes include uncontrolled shaking movements (e.g. tonic-clonic seizure involving much of the body with loss of consciousness), shaking movements (e.g. focal seizure involving only part of the body with variable levels of consciousness) and subtle momentary loss of awareness (e.g. absence seizure).

Seizures can be conceptualized as a result of the imbalance between excitation (E) and inhibition (I) in the brain. The factors that alter E/I balance can be genetic or acquired. These factors vary from genes and subcellular signaling cascades to widespread neuronal circuits, such as abnormal synaptic connectivity in cortical dysplasia, abnormal GABA receptor subunits in Angelman syndrome, potassium channel mutations in Brief Fear of Negative Evaluation Scale (BFNE) and structural alteration of hippocampal circuitry following prolonged febrile seizures.

Fig.1 Traumatic brain injury and epilepsy: underlying mechanisms leading to seizure.

Creative Biolabs provides all kinds of products that can be applied to neuroscientific research: the roles of genes versus acquired factors in seizure predisposition, how epilepsy develops and how to prevent the consequences of seizures. Our products include neural cell lines and specialty media, neural proteins and antibodies, cytokines, agonists and antagonists.

Pathways and Genes Related to Epilepsy and Seizures

Super pathways	Top Affiliating Genes
Transmission across chemical synapses	KCNV2, KCNQ3, KCNJ9, KCNJ4, KCNJ3, KCNJ16
Oxytocin signaling pathway	KCNJ9, KCNJ4, KCNJ3, KCNJ12
GABA receptor activation	KCNJ9, KCNJ4, KCNJ3, KCNJ16, KCNJ15, KCNJ12
Potassium channels	KCNV2, KCNQ3, KCNJ9, KCNJ4, KCNJ3, KCNJ16
Cardiac conduction	SCN8A, SCN1B, SCN1A, CACNB4, ATP1A3
Sudden infant death syndrome susceptibility pathway	GABRA1, CHRNB2, CHRNA4, ATP1A3
Phase 0 - rapid depolarisation	SCN8A, SCN1B, SCN1A, CACNB4

Epilepsy In Vitro Assay

For Research Use Only. Not For Clinical Use.

Target

CDK5

S100 Beta

HOMER1

NF2

Visinin-Like Protein 1

PIK3R1

BAX

GLP1

Huntingtin

alpha Elastin

SOD2

AMIGO-1

GALC

Sarcoplasmic Reticulum

Chromogranin B

Semaphorin 7a

GLI1

Glucagon

PAX5

Neuroligin 3

eNOS

CD11b

CacyBP

Dab1

Mint-1

Munc13-1

PGP9.5

APP

SAP97

Netrin G1

FABP2

IRR

Epilepsy and Seizures Related Research Tools

Pathways and Genes Related to Epilepsy and Seizures

Target

The Spectrum of Stem Cell-Based Neuronal Models and Their Fit for Purpose