Neuronal Electrophysiology Assay Services

Neuronal electrophysiology is a technique used to study the electrical activity of neurons and is widely used in neuroscience research. This assay records the bioelectrical signals of neurons to analyze their functions and characteristics. Creative Biolabs is a leading provider of neuronal electrophysiology solutions, offering customers cutting-edge tools to advance their research and accelerate the development of new treatments for neurological diseases. To learn more about our products and services, submit a project inquiry, or request pricing, please contact us.

Available Models

At Creative Biolabs, we provide a comprehensive range of in vitro electrophysiological assays, offering solutions tailored to your drug discovery requirements.

Neurons Electrophysiology Assay

• Patch-Clamp Electrophysiology

Our electrophysiology platform includes well-established manual patch-clamp recording technology, revered as the gold standard for electrophysiological characterization. This cutting-edge technology can help you obtain a thorough understanding of MoA information processing at the cellular level, as well as investigate therapeutic efficacy against specific targets. Moreover, we offer customizable procedures that can be tailored to individual requirements, ensuring precision and flexibility in experimental design.

Case Study: Whole-cell patch-clamp recordings were used in rodent DRG sensory neurons to evaluate compounds targeting membrane proteins in the context of pain drug discovery.

Fig.1 Representative image of patch-clamp. A) Rodent sensory neurons cultures. B) Dog and cynomolgus sensory neurons culture.

• Microelectrode array (MEA) assay

Microelectrode arrays (MEAs) are valuable tools for recording and quantifying neuronal action potentials. MEA is excellent for assessing how compounds of interest alter neuronal activity since many parameters are recorded simultaneously, such as mean firing rate, spike rate, burst duration, and network synchrony. At the same time, we have the Axion Biosystems system to help us achieve steady and dependable findings.

Fig.2 Primary rat spinal cultures were prepared and maintained in culture media for a minimum of 7 days, followed by treatments. Neuronal firing patterns are recorded using the Axion Biosystems system.

At Creative Biolabs, our neuronal electrophysiological services offer a unique advantage through their label-free, non-invasive multi-channel signal acquisition and real-time measurement capabilities. This technology enables continuous recording of cellular electrophysiological signals over extended periods, making it ideal for applications such as drug efficacy analysis, drug screening, and neural cell network research. We invite you to contact us to discuss your project plans in detail.