APP Transgenic Mouse Model Development Service

Our APP Transgenic Mouse Models, therefore, facilitate the acceleration of your research. They also enable the acquisition of reliable results. This is achieved through the application of advanced genetic engineering and comprehensive characterization.

How Our APP Transgenic Mouse Models Can Assist Your Project?

Deliverables, Solutions, and Key Problem-Solving Capabilities:

• Customizable Models: Creative Biolabs provides custom-generated APP transgenic mouse models tailored to your specific research objectives.
• Comprehensive Characterization: We deliver fully characterized models, including detailed reports on Aβ plaque pathology, neuroinflammation, synaptic integrity, and behavioral changes.
• Preclinical Efficacy Studies: Creative Biolabs offers in vivo efficacy studies to assess the impact of your therapeutic candidates on AD-related endpoints, providing critical data for your drug development pipeline.
• Data-Driven Insights: Our services generate reliable and reproducible data, enabling you to make informed decisions and advance your research with confidence.

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Workflow:

• Required Starting Materials: To initiate a project, clients typically provide the following:

Specific APP gene mutation(s) of interest.

Desired genetic background for the mouse model.

Research objectives, including key endpoints and study design considerations.

• Final Deliverables: Clients receive:

A fully characterized APP transgenic mouse model.

Detailed study reports, including raw and analyzed data.

Comprehensive documentation of the model generation and characterization process.

Estimated Timeframe: The typical timeframe for this service spans a range from 6 to 12 months. This duration, however, is contingent upon several factors. These factors encompass the complexity associated with model generation, the scope of characterization, and the specific design of any in vivo efficacy studies that may be involved.

Introduction

Advancing research on Alzheimer's disease (AD), distinguished pathologically by amyloid-β (Aβ) plaques and neurofibrillary tangles, relies heavily upon appropriate modeling systems. Transgenic mice engineered to overexpress mutant human amyloid precursor protein (APP) recapitulate essential amyloid characteristics, serving as vital tools for investigating pathogenesis and assessing potential therapeutics, thus enhancing the understanding of AD.

To meet research needs, a specific APP transgenic mouse model, produced via precise genetic engineering and validated by comprehensive characterization, offers a resource of potential utility. This model is intended to provide reliable datasets for amyloidogenesis studies and therapeutic efficacy screening, aiming to mitigate frequent modeling challenges and potentially accelerate advances toward treating this complex neurodegenerative condition.

Our APP Transgenic Mouse Models

We offer a wide range of the most mature and well-characterized transgenic mouse models.

Fig.1 Tg mouse models for AD research.¹

Fig.2 Western blot analysis of APP and APP-derived fragments in wild-type (WT), AppNL-F, and APP23 mice indicated that only APP23 mice produced APP and non-Aβ APP fragments in substantial abundance. And proteins that are overproduced in APP-overexpressing mice.²

Why Choose Us?

• Expertise: Creative Biolabs has extensive experience in generating and characterizing complex transgenic mouse models, with a team of experts in molecular biology, neuroscience, and animal model development.
• Advanced Technology: We utilize state-of-the-art genetic engineering techniques, including CRISPR/Cas9 gene editing, to ensure the precise and efficient generation of transgenic models.
• Customization: Creative Biolabs offers tailored solutions to meet the unique needs of each research project.
• Quality and Reliability: We adhere to the highest standards of quality control and animal care, ensuring the reliability and reproducibility of our models and data.
• Comprehensive Support: Creative Biolabs provides end-to-end support, from initial consultation and model generation to study execution and data analysis.
• Published Data: Creative Biolabs' models and services have contributed to numerous peer-reviewed publications, demonstrating their value in advancing AD research.

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Customer Reviews

"The support and consultation offered by Creative Biolabs' team were truly exceptional. Employing Creative Biolabs' APP Transgenic Mouse Models in our research has substantially deepened our comprehension. We specifically focused on the role of specific Aβ isoforms in this process." - Prof. Gar***a, Neurology Department Head.

FAQs

Related Services

Creative Biolabs offers a comprehensive portfolio of services to support your Alzheimer's disease research:

• Tau Transgenic Mouse Models: Models that exhibit tau pathology, another key feature of AD.
• Custom Antibody Development: Development of highly specific antibodies for your research needs.
• High Content Imaging (HCI) Assay Service: Detailed tissue analysis and imaging.

How to Contact Us

Investigators interested in obtaining further information on specific model characteristics or seeking consultation for project design are advised to contact the relevant scientific team at the institution.

References

1. Lopes, Paula Alexandra, Mafalda Soares Pádua, and José L. Guil-Guerrero. "An Overview of Transgenic Mouse Models for the Study of Alzheimer's Disease." Journal of Dementia and Alzheimer's Disease 2.1 (2025): 2. Distributed under Open Access license CC BY 4.0, without modification.
2. Sasaguri, Hiroki, et al. "APP mouse models for Alzheimer's disease preclinical studies." The EMBO journal 36.17 (2017): 2473-2487. Distributed under Open Access license CC BY 3.0, without modification.