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Creative Biolabs

Genetically Engineered Model Development Service

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons. Research has identified several genes linked to PD, including SNCA, LRRK2, PRKN, PINK1, and GBA1. Genetically engineered models (GEMs) are crucial tools for studying PD pathogenesis, elucidating disease mechanisms, and testing potential therapies. These models, often created using CRISPR/Cas9 technology, replicate key aspects of the disease in laboratory animals, allowing researchers to investigate the complex interplay of genetic and environmental factors. Creative Biolabs' Genetically Engineered Models for PD help you accelerate your research and obtain more physiologically relevant data through advanced CRISPR/Cas9 technology.

Workflow Advantages Available Models Customer Reviews Offerings Related Services FAQs

How Genetically Engineered Models Can Assist Your Project

Our genetically engineered models for provide you with tailored solutions, delivering precise animal models that accurately mimic the genetic complexities of PD. This enables more effective preclinical research, facilitating the development of targeted therapies and a deeper understanding of disease mechanisms.

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Workflow

CBL's workflow is designed to provide a streamlined and efficient process for generating custom genetically engineered models. Here's a detailed look at the key steps involved:

  • Required Starting Materials:
    • Specific gene sequence of interest (e.g., SNCA, LRRK2, PRKN).
    • Detailed information about the desired genetic modification (e.g., point mutation, knockout, conditional allele).
    • Preferred animal species and strain (e.g., mouse, rat).

Fig.1 Workflow of our Genetically Engineered Models Service. (Creative Biolabs Original)

  • Final Deliverables:
    • Detailed characterization report, including genotyping data, phenotypic analysis, and any relevant experimental findings.
    • Established line of genetically engineered animals, delivered as live animals or cryopreserved embryos.
    • Customized protocols and reagents, if required, to support your ongoing research.
  • Estimated Timeframe:
    • The typical timeframe for this service ranges from 26 to 52 weeks, depending on the complexity of the genetic modification, the animal species, and the extent of characterization required.

Why Choose Us?

CBL stands at the forefront of genetically engineered model development, offering unparalleled expertise and cutting-edge technologies to accelerate your research. Our commitment to precision, efficiency, and customer satisfaction ensures that you receive the highest quality models and support.

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Genetically Engineered Models For PD

Genetically engineered models are created by introducing specific genetic alterations into an organism's genome. These alterations can include:

  • Transgenic models: Overexpression of a gene implicated in PD, such as alpha-synuclein (SNCA).
  • Knockout models: Inactivation of a gene, such as parkin (PRKN) or PINK1, to study the effects of its absence.
  • Knock-in models: Insertion of a specific disease-causing mutation into the endogenous gene, more accurately mimicking the human condition.
  • Conditional models: Allow for spatial and temporal control of gene expression

Customer Reviews

"The precision and reliability of CBL's genetically engineered models have significantly improved our ability to study Parkinson's disease pathogenesis. The detailed characterization data provided was invaluable." Dr. A**a Patel, Neurobiology Institute.

"Using CBL's Genetically Engineered Models for Parkinson's Disease in our research has significantly facilitated the identification of novel therapeutic targets. The turnaround time was also impressive." Dr. M**k Smith, Biotech Innovations.

"CBL's expertise in CRISPR/Cas9 technology and their ability to generate complex models have greatly enhanced our understanding of gene function in Parkinson's disease. The support and consultation throughout the process were exceptional." Dr. J**e Brown, University Medical Center.

What we can offer

We offer a comprehensive service for the generation of Genetically Engineered Models for PD, with key advantages including:

  • Documentation quality and procedures of strain origin are assessed and approved by a qualified quality assurance service.
  • We guarantee the stability of strains in cell banks and large-scale in vivo model generation, including initial model creation and subsequent breeding.
  • We optimize the codon usage of genes to facilitate expression in selected animal models.
  • We offer flexibility in model generation, including traditional transgenic approaches and advanced gene editing.
  • We optimize in vivo model conditions to maximize the efficiency and relevance of the model.
  • High-standard quality control tools are employed to quantify and evaluate the quality and reliability of our genetically engineered models.

Related Services

CBL offers a comprehensive suite of related services to support your Parkinson's disease research:

  • Gene Synthesis: For generating DNA constructs with high accuracy.
  • Cell Line Engineering: To create cell-based models of PD.
  • Protein Expression and Purification: For producing high-quality recombinant proteins.

FAQs

Q How can CBL's genetically engineered models help me study specific Parkinson's disease-related genes?

A CBL utilizes CRISPR/Cas9 technology to create models with precise modifications in genes of interest, such as SNCA, LRRK2, and PRKN. These models allow you to investigate the impact of specific mutations on disease progression and test targeted therapies. Contact our team, and we can provide you with more gene-specific information.

Q What are the advantages of using CBL's models compared to other PD models?

A CBL's models offer increased precision and relevance to human PD due to the use of CRISPR/Cas9 technology. This results in more accurate replication of disease-causing mutations and a reduction in off-target effects. Reach out to us, and we can provide a detailed comparison.

Q Can CBL generate custom models tailored to my specific research needs?

A Yes, CBL specializes in generating custom genetically engineered models. Our team will work closely with you to design and create a model that precisely meets your research requirements. Inquire now to discuss your custom model.

Q What kind of support and data does CBL provide with its models?

A CBL provides comprehensive support, including detailed genotyping data, phenotypic characterization, and ongoing consultation with our scientific experts. We are dedicated to ensuring your research success. Contact us for more details.

Q How long does it take to generate a genetically engineered model with CBL?

A The timeline varies depending on the complexity of the model. We strive to deliver your model as efficiently as possible. Contact us for a project-specific estimate.
For Research Use Only. Not For Clinical Use.
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